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Contact

Coding Skills

Shell/Bash
NGS Data Analysis
High Performance Computing
R (Bioconductor, ggplot2, DESeq2)
Python
Containerization (Docker)
Databases

Languages

Disclaimer

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Last updated on 2025-08-25.

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Ricardo Linares Saldana

Aspiring pathologist dedicated to advancing patient care through the integration of genomics.

A physician-scientist with extensive training in genetics, epigenetics, and computational genomics. My research has evolved from wet-bench discovery to leading complex, large-scale sequencing analyses, providing me with a unique perspective on disease mechanisms. I am eager to apply this analytical and problem-solving skill set to the challenges of diagnostic pathology, with the ultimate goal of pursuing a fellowship in molecular pathology and contributing to the advancement of personalized medicine.

Education

MD, Medicine

Perelman School of Medicine

Philadelphia, PA

2023 - 2014

PhD, Genetics and Epigenetics

University of Pennsylvania

Philadelphia, PA

2021 - 2016

BS, Molecualr and Cellular Biology

The Johns Hopkins Universitry

Baltimore, MD

2012

Research Experience

Postdoctoral Research Fellow

Perelman School of Medicine

Philadelphia, PA

Current - 2023

  • Developed computational pipelines analyzing NGS data to investigate chromatin architecture and disease-relevant gene regulation.

Doctoral Student

University of Pennsylvania

Philadelphia, PA

2021

  • Principal Investigator: Rajan Jain, MD
  • Co-Mentor: Jonathan A. Epstein, MD

Undergraduate Researcher

The Johns Hopkins University

Baltimore, MD

2015

  • Principal Investigator: Haig Kazazian, MD

Undergraduate Researcher

University of Pennsylvania

Philadelphia, PA

2015

  • Principal Investigator: Michael Marks, PhD

Postbaccalaureate Research Fellow

National Institutes of Health

Bethesda, MD

2014

  • Principal Investigator: William Gahl, MD, PhD
  • Co-Mentor: Camilo Toro, MD

Publications

Transcription and Cohesin Direct Domain Boundary Spatial Positioning and Underpin Friedreich’s Ataxia

Cell, In Revision,

N/A

2025

  • Ashley Karnay, Ricardo Linares-Saldana, Qiaohong Wang, et al

Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen

bioRxiv, 10.1101/2025.08.13.670143

N/A

2025

  • Patrick J. Walsh, Elizabeth B. Kraeutler, Ricardo Linares-Saldana, et al

Genome folding and nuclear speckles converge to orchestrate fibroblast activation

In Preparation,

N/A

2025

  • Zachary Gardner, Ricardo Linares-Saldana, Krishna K. Haridhasapavalan, et al

Mesenchyme directed cytoskeletal-nuclear coupling regulates tissue regeneration

In Preparation,

N/A

2025

  • Dakota L. Jones, Sarah E. Schaefer, Ricardo Linares-Saldana, et al

A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation

Nature Cardiovascular Research, 10.1038/s44161-024-00431-1

N/A

2024

  • Arun Padmanabhan, … Ricardo Linares-Saldana, … Rajan Jain

BRD4 orchestrates genome folding to promote neural crest differentiation

Nature Genetics, 10.1038/s41588-021-00934-8

N/A

2021

  • Ricardo Linares-Saldana, Wonho Kim, Nikhita A. Bolar, et al

Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro

Cell Systems, 10.1016/j.cels.2021.07.003

N/A

2021

  • Ian A. Mellis, … Ricardo Linares-Saldana, … Arjun Raj

A transcriptional switch governs fibroblast activation in heart disease

Nature, 10.1038/s41586-021-03674-1

N/A

2021

  • Michael Alexanian, … Ricardo Linares-Saldana, … Deepak Srivastava

Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes

Cell Stem Cell, 10.1016/j.stem.2020.12.016

N/A

2021

  • Parisha P. Shah, … Ricardo Linares-Saldana, … Rajan Jain

BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes

Circulation, 10/gh59dw

N/A

2020

  • Arun Padmanabhan, Michael Alex, Ricardo Linares-Saldana, et al

Identification of a molecular basis for the juvenile sleep state

eLife, 10.7554/eLife.52676

N/A

2020

  • Leela C. Dilley, … Ricardo Linares-Saldana, … Matthew S Kayser

Targeting cardiac fibrosis with engineered T cells

Nature, 10/gf73rc

N/A

2019

  • Haig Aghajanian, … Ricardo Linares-Saldana, … Jonathan A. Epstein

Early lineage specification defines alveolar epithelial ontogeny in the murine lung

Proceedings of the National Academy of Sciences, 10/gfxfcq

N/A

2019

  • David B. Frank, … Ricardo Linares-Saldana, … Edward E. Morrisey

Centromere inheritance through the germline

Chromosoma, 10.1007/s00412-017-0640-y

N/A

2017

  • Arunika Das, Evan M. Smoak, Ricardo Linares-Saldana, et al

BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes

Current Biology, 10.1016/j.cub.2015.11.020

N/A

2016

  • Cédric Delevoye, … Ricardo Linares-Saldana, … Graça Raposo

Awards

NRSA F31 Grant Award

National Institutes of Health

N/A

2022 - 2019

Research Fellowship

The Center for Engineering MechanoBiology at UPenn

N/A

2021 - 2017

Research Travel Awards

Society for Advancement of Chicanos/Hispanics and Native Americans in Science, Graduate and Professional Student Assembly, and Biomedical Graduate Studies at UPenn

N/A

2018 - 2017