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BRD4 orchestrates genome folding to promote neural crest differentiation
Here we define a role for bromodomain-containing protein 4 (BRD4) in 3D genome organization and its interaction with the cohesin loader NIPBL. Results of our experiments demonstrate that BRD4 depletion results in decreased NIPBL binding to cromatin, compromised genome folding and loop extrusion, and impared cell differentiation.
Ricardo Linares Saldana, Wonho Kim, Nikhita A. Bolar, Haoyue Zhang, Bailey A. Koch-Bojalad, Sora Yoon, Parisha P. Shah, Ashley Karnay, Daniel S. Park, Jennifer M. Luppino, Son C. Nguyen, Arun Padmanabhan, Cheryl L. Smith, Andrey Poleshko, Qiaohong Wang, Li Li, Deepak Srivastava, Golnaz Vahedi, Gwang Hyeon Eom, Gerd A. Blobel, Eric F. Joyce, Rajan Jain
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BRD4 orchestrates genome folding to promote neural crest differentiation
Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in~vitro
Identifying the particular transcription factors that maintain cell type in~vitro is important for manipulating cell type. Identifying …
Ian A. Mellis, Hailey I. Edelstein, Rachel Truitt, Yogesh Goyal, Lauren E. Beck, Orsolya Symmons, Margaret C. Dunagin, Ricardo Linares Saldana, Parisha P. Shah, Juan A. Perez-Bermejo, Arun Padmanabhan, Wenli Yang, Rajan Jain, Arjun Raj
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A transcriptional switch governs fibroblast activation in heart disease
In diseased organs, stress-activated signalling cascades alter chromatin, thereby~triggering maladaptive cell state transitions. …
Michael Alexanian, Pawel F. Przytycki, Rudi Micheletti, Arun Padmanabhan, Lin Ye, Joshua G. Travers, Barbara Gonzalez Teran, Ana Catarina Silva, Qiming Duan, Sanjeev S. Ranade, Franco Felix , Ricardo Linares Saldana, Li Li, Clara Youngna Lee, Nandhini Sadagopan, Angelo Pelonero, Yu Huang, Gaia Andreoletti, Rajan Jain, Timothy A. McKinsey, Michael G. Rosenfeld, Casey A. Gifford, Katherine S. Pollard, Saptarsi M. Haldar, Deepak Srivastava
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Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes
(Abstract not available)
Parisha P. Shah, Wenjian Lv, Joshua H. Rhoades, Andrey Poleshko, Deepti Abbey, Matthew A. Caporizzo, Ricardo Linares Saldana, Julie G. Heffler, Nazish Sayed, Dilip Thomas, Qiaohong Wang, Liam J. Stanton, Kenneth Bedi, Michael P. Morley, Thomas P. Cappola, Anjali T. Owens, Kenneth B. Margulies, David B. Frank, Joseph C. Wu, Daniel J. Rader, Wenli Yang, Benjamin L. Prosser, Kiran Musunuru, Rajan Jain
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BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes
Background:Gene regulatory networks control tissue homeostasis and disease progression in a cell type–specific manner. Ubiquitously …
Arun Padmanabhan, Michael Alexanian, Ricardo Linares Saldana, Barbara Gonzalez Teran, Gaia Andreoletti, Yu Huang, Andrew J. Connolly, Wonho Kim, Austin Hsu, Qiming Duan, Sarah A.B. Winchester, Franco Felix , Juan A. Perez-Bermejo, Qiaohong Wang, Li Li, Parisha P. Shah, Saptarsi M. Haldar, Rajan Jain, Deepak Srivastava
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Identification of a molecular basis for the juvenile sleep state
Across species, sleep in young animals is critical for normal brain maturation. The molecular determinants of early life sleep remain …
Leela Chakravarti Dilley, Milan Szuperak, Naihua N Gong, Charlette E Williams, Ricardo Linares Saldana, David S Garbe, Mubarak Hussain Syed, Rajan Jain, Matthew S Kayser
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Targeting cardiac fibrosis with engineered T cells
Adoptive transfer of CAR T cells against the fibroblast marker FAP reduces cardiac fibrosis and restores function after cardiac injury …
Haig Aghajanian, Toru Kimura, Joel G. Rurik, Aidan S. Hancock, Michael S. Leibowitz, Li Li, John Scholler, James Monslow, Albert Lo, Wei Han, Tao Wang, Kenneth Bedi, Michael P. Morley, Ricardo Linares Saldana, Nikhita A. Bolar, Kendra McDaid, Charles-Antoine Assenmacher, Cheryl L. Smith, Dagmar Wirth, Carl H. June, Kenneth B. Margulies, Rajan Jain, Ellen Pure, Steven M. Albelda, Jonathan A. Epstein
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Early lineage specification defines alveolar epithelial ontogeny in the murine lung
During the stepwise specification and differentiation of tissue-specific multipotent progenitors, lineage-specific transcriptional …
David B. Frank, Ian J. Penkala, Jarod A. Zepp, Aravind Sivakumar, Ricardo Linares Saldana, William J. Zacharias, Katharine G. Stolz, Josh Pankin, MinQi Lu, Qiaohong Wang, Apoorva Babu, Li Li, Su Zhou, Michael P. Morley, Rajan Jain, Edward E. Morrisey
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Centromere inheritance through the germline
The centromere directs chromosome segregation and genetic inheritance but is not itself heritable in a canonical, DNA-based manner. In …
Arunika Das, Evan M. Smoak, Ricardo Linares Saldana, Michael A. Lampson, Ben E. Black
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BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes
Summary Recycling endosomes consist of a tubular network that emerges from vacuolar sorting endosomes and diverts cargoes toward the …
Cedric Delevoye, Xavier Heiligenstein, Lea Ripoll, Floriane Gilles-Marsens, Megan K. Dennis, Ricardo Linares Saldana, Laura Derman, Avanti Gokhale, Etienne Morel, Victor Faundez, Michael S. Marks, Graca Raposo
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